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KMID : 0370220010450060617
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Yakhak Hoeji
2001 Volume.45 No. 6 p.617 ~ p.622
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Antitumor Immunomodulatory Activity of PVP, a Protein-polysaccharide Fraction Prepared from a Wild Mushroom Psathyrella velutina
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정경수/Chung KS
이지선/Lee JS
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Abstract
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A protein-polysaccharide fraction of a Korean wild mushroom Pathyrella velutina, PVP, was prepared and its antitumor immunomodulatory activity was investigated. When PVP was administered once daily for seven days from day 1 to day 7 into male ICR mice implanted with 1 ×10^5 cells of sarcoma 180 tumor cells into the peritoneum on day 4, it inhibited the growth of sarcoma 180 cells by 92.8%. In XTT assay; PVP also exherted in vitro anti-proliferation activity on U-937, a human monoblastoid cell line, as well as sarcoma 180 cells. PVP showed marked stimulatory activity on the immune system in that it induced the accumulation of PEC (the stimulation index, Sl=4.90 at 100 mg/kg), stimulated the BALB/c mouse splenic Iymphocytes to form Iymphoblasts (Sl=5.75 at 100㎍/ml), and upregulated the expression of CD25 molecules. All these results strongly support that PVP exherts its antitumor activity through stimulation of the immune system as well as anti-proliferative activity on the tumor cells.
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KEYWORD
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